Thermo Fisher Scientific DENND1B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DENND1B. Recombinant protein control fragment (Product #RP-99838). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DENND1B,uniProtId:Q6P3S1-1,ncbiNodeId:9606,antigenRange:617-697,antigenLength:775,antigenImageFileName:PA5-60036_DENND1B_Q6P3S1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60036_DENND1B_Q6P3S1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640512

Product Specific Information

Immunogen sequence: AFLCGGSGDQ AEWNLGQDDS ALHGKHLPPS PRKRVSSSGL TDSLFILKEE NSNKHLGADN VSDPTSGLDF QLTSPEVSQT D

Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 67%.

Target Information

Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.