Thermo Fisher Scientific BIRC6/Apollon Polyclonal Antibody
BIRC6/Apollon 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, IP 등에 사용 가능. 1 mg/mL 농도의 액상 형태이며, 4°C 보관 및 Wet ice 배송. 세포사멸 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 4775 and the C-terminus (residue 4829) of human Baculoviral IAP repeat-containing protein 6 (BIRC6). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Application note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Apoptosis, or programmed cell death, is related to many diseases such as cancer. Apoptosis is triggered by a variety of stimuli including members of the TNF family and can be prevented by inhibitor of apoptosis (IAP) proteins.
IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.
BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain.
BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC through ubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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