Thermo Fisher Scientific RIMS2 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RIMS2 (NP_055492.2, 1 a.a. approximately 1163 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RIM2,uniProtId:Q9UQ26-6,ncbiNodeId:9606,antigenRange:1-1411,antigenLength:1411,antigenImageFileName:H00009699-D01P_RIM2_Q9UQ26-6_Rabbit.svg,antigenImageFileNamePDP:H00009699-D01P_RIM2_Q9UQ26-6_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE REEYSQYATS DTAMPRSPSD YADRRFQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDRSESVR PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT MTGHYNTISR MDRHRVMDDH YSPDRDSHFL TLPRSRYSQT IDHHHRDGRD CEAADRQPYH RSRSTEQRPL LERTTTRSRS TERPDTNLMR SMPSLMTGRS APPSPALSRS HPRTGSVQTS PSSTPVAGRR GRQLPQLPPK GTLDRKAGGK KLRSTVQRST ETGLAVEMRN WMTRQASRES TDGSMNSYSS EGNLIFPGVR LASDSQFSDF LDGLGPAQLV GRQTLATPAM GDIQVGMMDK KGQLEVEIIR ARGLVVKPGS KTLPAPYVKV YLLDNGVCIA KKKTKVARKT LEPLYQQLLS FEESPQGKVL QIIVWGDYGR MDHKSFMGVA QILLDELELS NMVIGWFKLF PPSSLVDPTL APLTRRASQS SLESSTGPSY SRS

Target Information

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.