Thermo Fisher Scientific Epstein-Barr Virus (LMP-1) Monoclonal Antibody (CS3)
Epstein-Barr Virus LMP-1 단백질을 인식하는 Mouse 모노클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 단백질 A/G 정제, PBS 버퍼에 보존, 연구용으로만 사용. EBV 관련 질환 연구 및 바이러스 단백질 발현 분석에 적합.
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Thermo Fisher Scientific Epstein-Barr Virus (LMP-1) Monoclonal Antibody (CS3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1.0 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CS3 |
| Immunogen | Recombinant fusion protein containing the sequence of bacterial beta-galactosidase and the carboxyl half of EBV-encoded LMP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Epstein-Barr virus (EBV) is a human herpesvirus associated with conditions such as Hodgkin’s disease and Burkitt’s lymphoma, and is the causative agent of mononucleosis in adolescents. EBV latently infects B lymphocytes, which express nuclear antigens and latent proteins LMP1, LMP2A, and LMP2B.
LMP2A aggregates in the plasma membranes of B lymphocytes and functions as a negative regulator of Src and Syk protein tyrosine kinases. Studies indicate that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV-immortalized B cells in vitro and may play an important role in maintaining latent EBV infection within peripheral blood B cells.
EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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