Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Desmoglein 3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 정제 방식으로 높은 순도(>95%)를 보장합니다. 세포 간 접착 연구 및 pemphigus vulgaris 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human POLR1C (Desmoglein 3, UniProt ID: P32926-1, antigen range: 1–999) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803520 |
Product Specific Information
- Purity >95% (by SDS-PAGE)
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion.
It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus.
Desmoglein 3 is characterized as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease.
Binding of anti-Desmoglein 3 autoantibodies causes loss of cell-cell adhesion, clinically manifesting as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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