Thermo Fisher Scientific SHROOM1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SHROOM1. Recombinant protein control fragment (Product #RP-96921). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SHROOM1,uniProtId:Q2M3G4-1,ncbiNodeId:9606,antigenRange:572-651,antigenLength:852,antigenImageFileName:PA5-58062_SHROOM1_Q2M3G4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58062_SHROOM1_Q2M3G4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647287

Product Specific Information

Immunogen sequence: LLDGLIPLAE VRAAMRPACG EAGEEAASTF EPGSYQFSFT QLLPAPREET RLENPATHPV LDQPCGQGLP APNNSIQGKK

Highest antigen sequence identity to the following orthologs: Mouse - 49%, Rat - 54%.

Target Information

SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM1 is a PDZ domain-containing actin-binding protein that is required for neural tube morphogenesis. It facilitates neurulation by regulating the morphology of neurepithelial cells via the apical positioning of an actomyosin network in the neurepithelium. SHROOM1 is also expressed in pulmonary arterial smooth muscle cells and its expression is significantly decreased in mouse and human models of pulmonary arterial hypertension, suggesting that there may be a link between SHROOM1 expression and pulmonary arterial hypertension.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.