Thermo Fisher Scientific GEMIN8 Polyclonal Antibody
Rabbit polyclonal antibody against human GEMIN8 단백질. Western blot에 최적화되어 있으며, Mouse 및 Rat 샘플과 반응 예측됨. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human GEMIN8 (UniProt ID: Q9NWZ8-1, Antigen range: 217–236, Length: 242 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691938 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is crucial for the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA. In the cytosol, these Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and facilitates transfer of Sm proteins to the SMN-Sm complex, triggering core snRNP assembly and nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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