Thermo Fisher Scientific GEMIN8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is crucial for the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA. In the cytosol, these Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and facilitates transfer of Sm proteins to the SMN-Sm complex, triggering core snRNP assembly and nuclear transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.