Thermo Fisher Scientific GPR68 Polyclonal Antibody
GPR68 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Mouse에 반응하며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. PBS(pH 7.4) 용액에 0.09% sodium azide가 포함되어 있으며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide (amino acids 200–225, central region of mouse GPR68) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634777 |
Product Specific Information
Predicted to react with bovine and human based on sequence homology.
Target Information
GPR68 (also known as OGR1, ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It functions as an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. GPR68 mediates its action through G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is nearly inactive at pH 7.8 but fully activated at pH 6.8. It also acts as a tumor suppressor in prostate cancer, and mutations in this gene are associated with amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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