Thermo Fisher Scientific KIF1C/LTXS1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

The kinesins constitute a large family of microtubule-dependent motor proteins responsible for distributing organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.

KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein abundantly expressed in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C-mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum.

KIF1C can form homodimers and noncovalently associate with 14-3-3 beta, gamma, epsilon, and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.