ELK Biotechnology ATG4a Rabbit pAb
Rabbit polyclonal antibody against ATG4a for IHC applications. Reacts with human, mouse, and rat. Recognizes a 45 kDa band. Supplied in PBS with glycerol and sodium azide, stored at -20 °C. Useful for studying autophagy-related proteins.
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ATG4a Rabbit Polyclonal Antibody
제품 개요
ELK Biotechnology의 ATG4a Rabbit pAb는 자가포식(autophagy) 관련 단백질 연구를 위한 토끼 유래 폴리클로날 항체입니다. 인간, 마우스, 랫트 시료에서 반응하며, IHC 실험에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ATG4a Rabbit pAb |
| Reactivity | Human, Mouse, Rat |
| Alternative Names | Apg4a, Atg4al, Autl2, Cysteine protease ATG4A antibody |
| Source | Rabbit |
| Applications | IHC |
| Species | Human |
| Recommended Dilutions | IHC 1:100–200 |
| Immunogen | Recombinant Protein |
| Storage | PBS with 0.02% sodium azide and 50% glycerol (pH 7.4). Store at -20 °C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kDa |
| Gene ID (Human) | 115201 |
| Human Swiss-Prot No. | Q8WYN0 |
| Cellular Localization | Cytoplasm |
Background
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg). Formation of autophagic vesicles requires a pair of essential ubiquitin-like conjugation systems, Atg12–Atg5 and Atg8–phosphatidylethanolamine (Atg8–PE), which are widely conserved in eukaryotes. Numerous mammalian counterparts to yeast Atg proteins have been described, including three Atg8 proteins (GATE-16, GABARAP, and LC3) and four Atg4 homologs (Atg4A/autophagin-2, Atg4B/autophagin-1, Atg4C/autophagin-3, and Atg4D/autophagin-4).
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