ELK Biotechnology ATG4c Rabbit pAb
ATG4c 단백질을 인식하는 토끼 폴리클로날 항체로, 인간·마우스·랫에서 반응합니다. IHC 분석에 적합하며 1:100~200 희석 사용을 권장합니다. 세포질에 위치한 ATG4c 단백질 검출에 유용하며, 자가포식 관련 연구에 활용됩니다.
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ATG4c Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ATG4c Rabbit pAb |
| Reactivity | Human, Mouse, Rat |
| Alternative Names | APG4C, Autl3, Cysteine protease ATG4C antibody |
| Source | Rabbit |
| Applications | IHC |
| Species | Human |
| Recommended dilutions | IHC 1:100–200 |
| Immunogen | Recombinant Protein |
| Storage | PBS with 0.02% sodium azide and 50% glycerol, pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed band | 57 kDa |
| Gene ID (Human) | 84938 |
| Human Swiss-Prot No | Q96DT6 |
| Cellular localization | Cytoplasm |
Background
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg). Formation of autophagic vesicles requires a pair of essential ubiquitin-like conjugation systems, Atg12–Atg5 and Atg8–phosphatidylethanolamine (Atg8–PE), which are widely conserved in eukaryotes. Numerous mammalian counterparts to yeast Atg proteins have been described, including three Atg8 proteins (GATE-16, GABARAP, and LC3) and four Atg4 homologs (Atg4A/autophagin-2, Atg4B/autophagin-1, Atg4C/autophagin-3, and Atg4D/autophagin-4).
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