ELK Biotechnology CACNA1C rabbit pAb
CACNA1C 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에서 반응하며 세포막 단백질 분석에 유용합니다. 고순도 IgG 형식으로 -20°C에서 1년 보관 가능합니다.
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CACNA1C rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CACNA1C rabbit pAb |
| Alternative Names | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human CACNA1C (AA range: 1100–1180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160–240 kD |
| GeneID (Human) | 775 |
| Human Swiss-Prot No. | Q13936 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
- Cell membrane; Multi-pass membrane protein
- Sarcolemma; Multi-pass membrane protein
- Perikaryon
- Cell junction, synapse, postsynaptic density membrane
- Cell projection, dendrite
- Cell membrane, sarcolemma, T-tubule
- Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact
- The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane
Background
Calcium voltage-gated channel subunit alpha1C (CACNA1C) is a human gene encoding the alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx upon membrane polarization. The alpha-1 subunit, consisting of 24 transmembrane segments, forms the pore through which ions pass. The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Multiple isoforms arise from different genes or alternative splicing. The encoded protein binds to and is inhibited by dihydropyridine. Alternative splicing results in various transcript variants, some of which may not produce functional ion channel subunits. (RefSeq, Oct 2012)
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