ELK Biotechnology CACNA1C rabbit pAb

CACNA1C rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

• Cell membrane; Multi-pass membrane protein
• Sarcolemma; Multi-pass membrane protein
• Perikaryon
• Cell junction, synapse, postsynaptic density membrane
• Cell projection, dendrite
• Cell membrane, sarcolemma, T-tubule
• Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact
• The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane

Background

Calcium voltage-gated channel subunit alpha1C (CACNA1C) is a human gene encoding the alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx upon membrane polarization. The alpha-1 subunit, consisting of 24 transmembrane segments, forms the pore through which ions pass. The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Multiple isoforms arise from different genes or alternative splicing. The encoded protein binds to and is inhibited by dihydropyridine. Alternative splicing results in various transcript variants, some of which may not produce functional ion channel subunits. (RefSeq, Oct 2012)