ELK Biotechnology DR5 rabbit pAb
DR5 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 생쥐, 랫트 시료에 반응합니다. WB 및 ELISA에 사용 가능하며, 세포막 단백질 DR5의 세포사멸 신호 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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DR5 rabbit pAb
제품 개요
DR5 rabbit pAb는 Tumor necrosis factor receptor superfamily member 10B (Death receptor 5; TRAIL receptor 2; CD262)를 인식하는 토끼 폴리클로날 항체입니다. 세포사멸(apoptosis) 신호 전달 경로 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DR5 rabbit pAb |
| Alternative Names | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD antigen CD262) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human DR5 (AA range: 200–280) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 8795 |
| Human Swiss-Prot No. | O14763 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL/APO-2L) and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. (RefSeq, Mar 2009)
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