ELK Biotechnology FAK (Phospho Ser722) rabbit pAb

FAK (Phospho Ser722) rabbit pAb

제품 개요

Focal adhesion kinase (FAK)는 세포 부착, 이동, 증식, 세포사멸 등의 신호전달에 관여하는 비수용체형 단백질 티로신 키나아제입니다. 본 항체는 인간 FAK의 인산화된 Ser722 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다.

제품 정보

Background

• Catalytic activity: ATP + a [protein]-L-tyrosine → ADP + a [protein]-L-tyrosine phosphate
• Domains:
  • C-terminal region contains the focal adhesion targeting (FAT) sequence that mediates localization to focal adhesions.
  • The first Pro-rich domain interacts with SH3 domain of CRK-associated substrate (BCAR1) and CASL.
• Function:
  Non-receptor protein-tyrosine kinase involved in cell motility, proliferation, and apoptosis signaling. Activated by tyrosine phosphorylation in response to integrin clustering, GPCR ligands (e.g., bombesin, lysophosphatidic acid), or LDL receptor occupancy. Plays a role in oncogenic transformation with increased kinase activity.
• PTM: Phosphorylated on six tyrosine residues upon activation.
• Similarity: Belongs to the protein kinase superfamily (Tyr protein kinase family, FAK subfamily); contains one FERM domain and one protein kinase domain.
• Subunit interactions: Interacts with CAS family members, GIT1, SORBS1, BCAR3, RGNEF, SHB, and TGFB1I1.
• Tissue specificity: Expressed in all organs tested, most abundantly in brain and lymphoid cell lines.

제품 이미지

(이미지 없음)