ELK Biotechnology TSC2 (Phospho Ser1254) rabbit pAb
인간 TSC2 단백질의 인산화형(Ser1254)을 인식하는 토끼 폴리클로날 항체. WB 및 ELISA에 적합하며 세포 성장 조절 연구에 활용 가능. -20°C에서 1년 보관 가능하며 Human, Mouse, Rat 시료에 반응.
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제품명
TSC2 (Phospho Ser1254) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Tuberin (Tuberous sclerosis 2 protein) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human TSC2 (Phospho Ser1254) |
| Host | Rabbit |
| Storage | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 73 kD |
| Gene ID (Human) | 7249 |
| Human Swiss-Prot No | P49815 |
| Cellular Localization | Cytoplasm; Membrane; Peripheral membrane protein. Found in association with membranes at steady state. |
| Species Reactivity | Human; Mouse; Rat |
Background
Defects in TSC2 are associated with lymphangioleiomyomatosis (LAM) [MIM:606690], a progressive lung disease affecting mainly young women, and tuberous sclerosis complex (TSC) [MIM:191100], an autosomal dominant multi-system disorder involving benign overgrowths (hamartomas) and developmental abnormalities (hamartias) in various organs.
TSC2 functions as a tumor suppressor, potentially involved in vesicular transport and cell growth regulation. Interaction between TSC1 and TSC2 facilitates vesicular docking and stimulates intrinsic GTPase activity of RAP1A and RAB5, contributing to growth regulation.
Mutations in TSC2 can lead to constitutive activation of RAP1A in tumors.
Additional Information
- PTM: Phosphorylation at Ser-1387, Ser-1418, or Ser-1420 does not affect interaction with TSC1.
- Similarity: Contains one Rap-GAP domain.
- Subunit Interaction: Interacts with TSC1 and HERC1; stabilized by TSC1 interaction. May also interact with RABEP1, forming a complex linked to RAB5. Interacts with HSPA1 and HSPA8.
- Tissue Specificity: Expressed in liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung, and placenta.
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