ELK Biotechnology BRSK2 (Phospho Thr260) rabbit pAb

BRSK2 (Phospho Thr260) rabbit pAb

제품 개요

BRSK2 (Phospho Thr260) rabbit polyclonal antibody는 인간 BRSK2 단백질의 Thr260 인산화 부위에서 유래한 합성 펩타이드를 면역원으로 제작되었습니다. WB 및 ELISA 분석에 적합하며, 세포 내 미세소관 조직 및 신경세포 극성 형성 연구에 활용됩니다.

제품 정보

세포 내 위치

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Activated by phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRADα) pseudo kinase and CAB39
• Function: Required for the polarization of forebrain neurons, possibly by regulating phosphorylation of microtubule-associated proteins
• Similarity: Belongs to the protein kinase superfamily (CAMK Ser/Thr protein kinase family, AMPK subfamily); contains 1 protein kinase domain