ELK Biotechnology TLK1 (Phospho Ser764) rabbit pAb

제품명

TLK1 (Phospho Ser764) rabbit pAb

제품 개요

TLK1 (Phospho Ser764) rabbit pAb는 인산화된 Ser764 부위를 타겟으로 하는 폴리클로날 항체로, TLK1 단백질의 세포주기 조절 및 DNA 손상 반응 연구에 활용됩니다.

제품 정보

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHK1.
• Function: Rapidly and transiently inhibited by phosphorylation following DNA double-stranded breaks during S-phase. This inhibition is cell cycle checkpoint and ATM-pathway dependent, regulating chromatin assembly processes. Isoform 3 phosphorylates and stabilizes t-SNARE SNAP23, enhancing its assembly with syntaxin, and protects cells from ionizing radiation by facilitating DSB repair. In vitro, phosphorylates histone H3 at Ser-10.
• Similarity: Belongs to the protein kinase superfamily; Ser/Thr protein kinase family; contains one protein kinase domain.
• Subunit: Heterodimerizes with TLK2; interacts with ASF1A and ASF1B.
• Tissue specificity: Widely expressed — present in fetal placenta, liver, kidney, and pancreas but not in heart or skeletal muscle. Isoform 3 is ubiquitously expressed in all examined tissues.