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ELK Biotechnology c-Myb (Acetyl Lys480) rabbit pAb
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ELK Biotechnology c-Myb (Acetyl Lys480) rabbit pAb

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c-Myb (Acetyl Lys480) rabbit pAb는 인간 및 마우스 시료에 반응하는 폴리클로날 항체로, WB와 ELISA에 적합합니다. 핵 내 전사 활성화 단백질 c-Myb의 아세틸화된 Lys480 부위를 인식하며, 세포 증식 및 분화 연구에 활용됩니다.

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pk
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ELK Biotechnology ES20115-100UL c-Myb (Acetyl Lys480) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES20115-50UL c-Myb (Acetyl Lys480) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology c-Myb (Acetyl Lys480) rabbit pAb

제품명

c-Myb (Acetyl Lys480) rabbit pAb

제품 정보

항목 내용
Alternative Names Transcriptional activator Myb (Proto-oncogene c-Myb)
Applications WB; ELISA
Recommended Dilutions WB 1:1000–2000, ELISA 1:5000–20000
Immunogen Synthesized peptide derived from human c-Myb (Acetyl Lys480)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 70 kD
GeneID (Human) 4602
Human Swiss-Prot No. P10242
Cellular Localization Nucleus
Species Reactivity Human; Mouse

Background

The c-Myb protein is a transcriptional activator composed of three domains: an N-terminal DNA-binding domain, a central transcriptional activation domain, and a C-terminal repression domain. It specifically recognizes the DNA sequence 5'-YAAC[GT]G-3', playing a critical role in regulating proliferation and differentiation of hematopoietic progenitor cells.

  • Function: Transcriptional activator; DNA-binding protein recognizing 5'-YAAC[GT]G-3'.
  • Post-translational Modifications (PTM):
    • Phosphorylated by NLK on multiple sites, leading to proteasomal degradation.
    • Ubiquitinated via SIAH1, promoting degradation.
  • Similarity: Contains three HTH myb-type DNA-binding domains.
  • Subunit Interaction: Binds MYBBP1A; interacts with HIPK2, MAF, and NLK.

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