ELK Biotechnology MEF-2A/C (Acetyl Lys3) rabbit pAb
MEF-2A/C (Acetyl Lys3) rabbit pAb는 인간 MEF-2A/C 단백질의 아세틸화된 Lys3 잔기를 인식하는 폴리클로날 항체입니다. WB 및 ELISA에 적합하며, 핵 내 MEF2A/C 단백질 검출에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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MEF-2A/C (Acetyl Lys3) rabbit pAb
제품 개요
이 항체는 인간 MEF-2A/C 단백질의 아세틸화된 Lys3 부위를 특이적으로 인식하는 rabbit 폴리클로날 항체입니다. 근육 및 신경세포에서 MEF2A/C 단백질의 기능 연구에 적합하며, WB 및 ELISA 분석에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MEF-2A/C (Acetyl Lys3) rabbit pAb |
| Alternative Names | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human MEF-2A/C (Acetyl Lys3) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| GeneID (Human) | 4205 |
| Human Swiss-Prot No | Q02078 / Q06413 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
Defects in MEF2A may cause autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [MIM:608320].
MEF2A acts as a transcriptional activator binding to MEF2 elements found in muscle-specific genes and regulates growth factor- and stress-induced genes. It plays roles in skeletal and cardiac muscle development, neuronal differentiation, and survival.
Post-translational modifications (PTMs) include acetylation, phosphorylation, sumoylation, and proteolytic cleavage, which modulate transcriptional activity, apoptosis, and differentiation.
MEF2A belongs to the MEF2 family and contains one MADS-box domain and one Mef2-type DNA-binding domain. It forms homo- or heterodimers, interacts with HDACs, PIAS1, and MAPK7, and exhibits tissue-specific expression in muscle and brain.
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