Thermo Fisher Scientific CBFB/PEBP2beta Monoclonal Antibody (PCRP-CBFB-1F6)

Applications and Tested Dilutions

Product Specifications

Target Information

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. This family regulates genes involved in hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit acts as a non-DNA-binding regulatory subunit that enhances DNA binding by the alpha subunit. The complex binds to core sites of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.

Alternative splicing generates two mRNA variants encoding distinct carboxyl termini. A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can produce a chimeric transcript combining the N terminus of core-binding factor beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype). Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.