Thermo Fisher Scientific CBFB/PEBP2beta Monoclonal Antibody (PCRP-CBFB-1F6)
CBFB/PEBP2beta 단백질을 인식하는 mouse monoclonal antibody로, Western blot, ICC/IF, Flow cytometry, ELISA, IP 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, Protein A/G로 정제된 액상 형태로 제공됩니다. 연구용 전용 시약입니다.
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- 865-MSM1-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1–2 µg/500 µg lysate |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-CBFB-1F6 |
| Immunogen | Recombinant full-length human CBFB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. This family regulates genes involved in hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit acts as a non-DNA-binding regulatory subunit that enhances DNA binding by the alpha subunit. The complex binds to core sites of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.
Alternative splicing generates two mRNA variants encoding distinct carboxyl termini. A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can produce a chimeric transcript combining the N terminus of core-binding factor beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype). Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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