Thermo Fisher Scientific CD8A Monoclonal Antibody (UMAB241), UltraMAB
인간 CD8A 단백질을 표적으로 하는 Thermo Fisher Scientific의 UMAB241 단클론 항체입니다. 파라핀 포매 조직 IHC에 적합하며, 마우스 IgG1 형식의 비결합 액상 항체입니다. 신호전달 및 T세포 활성화 연구용으로 사용됩니다.
- 카탈로그번호
- UM870133
- 판매단위
- pk
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Thermo Fisher Scientific CD8A Monoclonal Antibody (UMAB241), UltraMAB
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB241 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–182 of human CD8A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Engagement of MHC-I/peptide complexes on antigen-presenting cells triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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