Thermo Fisher Scientific Lamin A Recombinant Rabbit Monoclonal Antibody (4H7)
Thermo Fisher Scientific의 Lamin A Recombinant Rabbit Monoclonal Antibody (4H7)은 인간 Lamin A 단백질을 인식하는 고특이성 항체입니다. IHC, ICC/IF, Flow Cytometry, ELISA, IP 등 다양한 응용에 적합합니다. 고순도 정제된 액상 형태로 안정적이며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | 1:200–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4H7 |
| Immunogen | A synthesized peptide derived from human LMNA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092604 |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, arising from the same gene by alternative splicing. B-type lamins include lamin B1 and lamin B2, derived from distinct genes.
Mutations in A-type lamins are associated with several rare but dominant genetic disorders, such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
Expression of A-type lamins correlates with cell differentiation, and their interaction with chromatin suggests a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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