Thermo Fisher Scientific HIF3A Monoclonal Antibody (OTI5B7), TrueMAB
인간 HIF3A 단백질(aa 355-669)을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot에 1:500 희석으로 사용 가능하며, 액상 형태로 제공됩니다. PBS/BSA/glycerol buffer에 보관하며 -20°C에서 안정적으로 저장됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B7 |
| Immunogen | Human recombinant protein fragment (aa 355–669 of HIF3A, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (Arnt1), EPAS-1 (HIF-2α), and HIF-3α, induce glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis. These factors belong to the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt1, creating the HIF-1 complex. This complex binds to hypoxia responsive elements (HRE) of target genes to activate transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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