Thermo Fisher Scientific SYNPO2 Polyclonal Antibody
Human SYNPO2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:500~1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, PBS 및 글리세롤 버퍼에 보존. 근육 및 세포골격 연구에 활용 가능.
- 카탈로그번호
- PA556534
- 판매단위
- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SYNPO2. Recombinant protein control fragment (Product #RP-95491) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648147 |
Product Specific Information
Immunogen sequence:
EDKVGGTPSR EQDAAQTDGL RTTTSYQRKE EESVRTQSSV SKSYIEVSHG LGHVPQQNGF SGASETANIQ RMVPMNRTAK PFPGSVNQPA T
Highest antigen sequence identity to the following orthologs:
- Mouse: 68%
- Rat: 69%
Target Information
SYNPO2, also known as myopodin, is a member of the synaptopodin family containing one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is localized at the Z-disc. Under stress conditions, it translocates to the nucleus, suggesting a signaling role in addition to its structural function. SYNPO2 interacts with calmodulin, alpha-actinin, and smooth muscle myosin, promoting actin polymerization in a calmodulin-dependent manner. This supports its role in cytoskeletal organization. Alterations in SYNPO2 expression have been associated with prostate cancer invasiveness and motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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