Thermo Fisher Scientific Quinidine Monoclonal Antibody (QD11-265.2.3)

Applications

• ELISA (ELISA)
  Tested Dilution: 1–10 µg/mL

Product Specifications

Product Specific Information

• MA1-10748 detects Quinidine.
• MA1-10748 has been successfully used in ELISA applications.
• The MA1-10748 immunogen is Quinidine, conjugated to KLH.

Target Information

Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses. This results in an increased threshold for excitation and decreased depolarization during phase 0 of the action potential. Additionally, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, leading to decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite, preventing further polymerization by the heme polymerase enzyme. This causes accumulation of toxic heme and death of the parasite.
[Source: National Center for Biotechnology Information. PubChem Compound Database; CID=441074]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.