Thermo Scientific™

CT(PEG)12 Carboxy-PEG-Thiol Compound

Thermo Scientific Pierce CT(PEG)12, or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer자세히 알아보기

Thermo Scientific Pierce CT(PEG)12, or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.

CT(PEG)12 is monodentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate handles for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides.

Features of carboxy-PEG12-thiol:

• Metal-binding—terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding
• Carboxylate—terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry
• Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
• Spacer arm—12-unit PEG spacer is nearly 48 angstroms long, minimizing steric hindrance for protein immobilization and binding assays

The use of MT(PEG)4 with CT(PEG)12 in surface modification can form a hydrophilic lawn of methyl ether-terminated PEGs with periodic exposed carboxylic acid-containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

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사양

화학물질 반응성Amine

라벨 유형Conjugating Groups, Polyethylene Glycol (PEG)

반응성 부분Carboxylic Acid, Thiol

스페이서12 ethylene glycol units

형태Solid

수량100 mg

용해도DMF or DMSO

제품 유형Thiol Compound

Unit SizeEach