Thermo Fisher Scientific Sigma-1 Receptor Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

View 19 publications 19 publications

Immunohistochemistry (IHC)

-

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Functional Assay (Functional)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse, Rat

Published species

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal region of the rat sigma-1 receptor, which differs from mouse and human by one conservative amino acid change and is predicted to be identical to dog, bovine, and ermine if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Sigma-1 Receptor,uniProtId:Q9R0C9-1,ncbiNodeId:10114,antigenRange:223,antigenLength:223,antigenImageFileName:42-3300_Sigma-1_Receptor_Q9R0C9-1_Rabbit.svg,antigenImageFileNamePDP:42-3300_Sigma-1_Receptor_Q9R0C9-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533521

Product Specific Information

This antibody is specific for the sigma-1 receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1) protein. On western blots, it identifies the target band at ~25 kDa. Reactivity has been confirmed with rat brain, rat liver, and mouse brain homogenates. Based on amino acid sequence identity, reactivity with human, bovine, dog, and ermine is expected.

Target Information

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.