Thermo Fisher Scientific Sigma-1 Receptor Polyclonal Antibody
Sigma-1 수용체를 인식하는 토끼 폴리클로날 항체로, WB, IHC, ICC/IF, 기능 분석에 사용 가능. Rat 및 Mouse 시료에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4)에 0.1% sodium azide 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 19 publications |
| Immunohistochemistry (IHC) | – | View 4 publications |
| Immunocytochemistry (ICC/IF) | – | View 2 publications |
| Functional Assay | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the rat sigma-1 receptor, differing from mouse and human by one conservative amino acid change; predicted to be identical to dog, bovine, and ermine. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533521 |
Product Specific Information
This antibody specifically recognizes the sigma-1 receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1).
In Western blot analysis, it detects a target band at approximately 25 kDa.
Confirmed reactivity with rat brain, rat liver, and mouse brain homogenates.
Based on sequence identity, reactivity with human, bovine, dog, and ermine is expected.
Target Information
The sigma-1 receptor gene encodes a receptor protein that interacts with various psychotomimetic drugs such as cocaine and amphetamines.
It plays a key role in cellular functions across endocrine, immune, and nervous systems.
Previously misclassified as an opioid receptor (OPRS1), it is now recognized as a non-opioid receptor.
Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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