Thermo Fisher Scientific TCL1A Polyclonal Antibody
Human TCL1A 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 암 관련 연구 및 AKT 신호전달 연구에 적합.
- 카탈로그번호
- PA582554
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TCL1A (Product #RP-88939) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789712 |
Product Specific Information
Immunogen sequence:
AECPTLGEAV TDHPDRLWAW EKFVYLDEKQ HAWLPLTIEI KDRLQLRVLL RREDVVLGRP MTPTQIGPSL LPIMWQLYPD GRYRSSDSSF WRLVYHIKID GVEDMLLE
Target Information
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (Virgilio et al., 1998).
In normal T cells, TCL1 is expressed in CD4-/CD8- cells but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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