Thermo Fisher Scientific Cardiac Troponin I Polyclonal Antibody

Applications

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin–tropomyosin complex, anchored by the binding of TnI to actin within muscle thin filaments. Structural changes resulting from calcium binding to the regulatory TnC subunit release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction. Measurement of blood TnI and TnT levels serves as an important diagnostic indicator of heart muscle damage and helps differentiate between angina and myocardial infarction. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.