Thermo Fisher Scientific LYVE-1 Polyclonal Antibody
인간 및 마우스 LYVE-1 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 사용 가능. Protein A 정제 및 1 mg/mL 농도. 림프관 특이적 마커 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human LYVE1, amino acids 51–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
LYVE1 has been identified as a major receptor for hyaluronan (HA) on the lymph vessel wall. The deduced amino acid sequence predicts a 322-residue type I integral membrane polypeptide, 41% similar to the CD44 HA receptor. It includes a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily.
Like CD44, LYVE1 binds both soluble and immobilized HA. However, unlike CD44, LYVE1 colocalizes with HA on the luminal face of lymph vessels and is absent from blood vessels. Therefore, LYVE1 serves as a lymph-specific HA receptor and a powerful marker for lymphatic vessels.
LYVE-1 is expressed primarily on lymphatic vessel endothelium and may regulate leukocyte and tumor cell trafficking to lymph nodes. The lymphatic vasculature drains extracellular fluid and provides an environment for immune cell responses. Known lymphatic endothelial markers include LYVE1, PALE, VEGFR3, and podoplanin. Diseases associated with LYVE1 dysfunction include Complete Androgen Insensitivity Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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