Thermo Fisher Scientific ULK1 (denatured) Polyclonal Antibody
ULK1 단백질 인산화효소를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, Flow cytometry에 적합. 사람 및 생쥐 반응성. 자가포식 연구용으로 활용 가능. 연구용 한정.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Denatured human ATG1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion – Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543626 |
Target Information
ULK1 is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy, a vital cellular response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 regulates its function and localization. Knockdown of ULK1 inhibits autophagic response and rapamycin-induced autophagy, consistent with its role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13, essential for starvation-induced autophagy, proper localization to the pre-autophagosome, and ULK1 protein stability. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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