Thermo Fisher Scientific RHBDD3 Polyclonal Antibody
RHBDD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 적합하며 인간 시료 반응성. 항원 친화 크로마토그래피로 정제, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RHBDD3. Recombinant protein control fragment (Product #RP-99855). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646526 |
Product Specific Information
Immunogen sequence:
HWEDSALPPP SLRPVQPTWE GSSEAGLDWA GASFSPGTPM WAALDEQMLQ EGIQASLLDG PAQEPQSAPW LSKSSVSSL
Antigen sequence identity:
- Mouse: 66%
- Rat: 62%
Target Information
The Rhomboid family of proteins consists of conserved polytopic membrane serine proteases involved in growth and development. RHBDD3 was identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression is reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells increases apoptotic activity and caspase activation in response to bromocriptine, suggesting potential therapeutic value. Reduced RHBDD3 expression in colorectal tumors indicates that its loss may contribute to decreased apoptosis and malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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