Thermo Fisher Scientific Human Fas Ligand (soluble) Recombinant Protein, PeproTech
Human Fas Ligand (soluble) recombinant protein from Thermo Fisher Scientific. Expressed in CHO cells with His-tag, ≥95% purity, and <1 EU/µg endotoxin. Induces cytotoxicity in Jurkat cells with ED50 ≤10 ng/ml. Lyophilized form for research use only.
- 카탈로그번호
- 310-03H-xxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human Fas Ligand (soluble) Recombinant Protein, PeproTech
Applications
- Functional Assay (Assay-dependent)
- In vitro Assay
- Miscellaneous PubMed references available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse, Rat |
| Expression System | CHO cells |
| Amino Acid Sequence | HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL |
| Tag | His-tag |
| Molecular Weight | 17.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Induces cytotoxicity in Jurkat cells without cross-linking; ED50 ≤ 10.0 ng/ml (≥ 1 x 10^5 units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human soluble Fas Ligand is a 17.9 kDa protein comprising the TNF-homologous region of FasL and contains an 8-residue N-terminal His-Tag.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
CD178 (Fas ligand, FasL) is a type-II membrane protein with its N-terminus in the cytoplasm and C-terminal region extending into the extracellular space. Its receptor, FasR, is a type-I membrane protein belonging to the TNF and NGF receptor family.
CD178 induces apoptosis upon interaction with FasR and can exist in both membrane-bound (45 kDa) and soluble (26 kDa) forms, the latter released via metalloproteinase cleavage.
Binding of CD178 to Fas triggers receptor oligomerization and apoptotic signaling. CD178 is predominantly expressed in activated T-lymphocytes and NK cells, as well as immune-privileged sites (testis, eye) and other tissues (thymus, liver, ovary, lung, heart, kidney).
Its role is central to antiviral immune responses and regulation of immune reactions. Altered CD178 expression has been associated with atherosclerosis, inflammatory disease, hypertension, AIDS, hepatitis, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.