Thermo Fisher Scientific PTPN2 Polyclonal Antibody
PTPN2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간 단백질에 반응하며, 액상 형태로 제공. PBS 및 2% sucrose buffer에 보관, -20°C에서 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human PTPN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609314 |
Product Specific Information
Peptide sequence:
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 100%
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins.
This enzyme has two C-terminal splice variants with distinct subcellular localizations:
- 45 kDa isoform: Exclusively nuclear in resting cells, redistributes to cytosol upon stimulation with growth factors or stress.
- 48 kDa isoform: Found in the endoplasmic reticulum, with distinct physiological substrates.
TC-PTP is expressed in various tissues, particularly in hematopoietic cells. Knockout mice lacking TC-PTP exhibit erythropoietic and lymphopoietic deficits, indicating its critical role in bone marrow maturation.
It dephosphorylates a wide range of phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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