Thermo Fisher Scientific CD366 (TIM3) Polyclonal Antibody
Rabbit polyclonal antibody against human TIM3 (CD366). Validated for Western blot with 0.01–2 µg/mL dilution. Purified by antigen affinity chromatography and supplied in PBS with 50% glycerol. Suitable for research use only.
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Applications
- Western Blot (WB): 0.01–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Hepatitis A Virus Cellular Receptor 2 (amino acids 22–202 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903688 |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells. It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and autoimmune disease induction, acting to down-regulate Th1-mediated immune responses and promote immune tolerance. It plays roles in experimental autoimmune encephalomyelitis (EAE) and other Th1-dependent autoimmune conditions.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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