Thermo Fisher Scientific Human PIASy Synthetic Peptide
Human PIASy 단백질의 N-말단 19개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20954 항체의 블로킹 펩타이드로 사용 가능. SUMO 결합 효소 기능 연구에 적합한 연구용 시약. 고순도 정제, PBS 버퍼에 0.1% BSA 포함, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human PIAS4.
PEP-1068 can be used as a blocking peptide with polyclonal antibody PA5-20954.
Target Information
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.
Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT, p53/TP53, Wnt, and steroid hormone signaling pathways.
Involved in gene silencing and mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4, and RNF168.
In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.
Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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