Thermo Fisher Scientific GRB10 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MNASLESLYS ACSMQSDTVP LLQNGQHARS QPRASGPPRS IQPQVSPRQR VQRSQPVHIL AVRRLQEEDQ QFRTSSLPAI PNPFPELCGP GSPPVLTPGS LPPSQAAAKQ DVKVFSEDGT SKVVEILADM TARDLCQLLV YKSHCVDDNS WTLVEHHPHL GLERCLEDHE LVVQVESTMA SESKFLFRKN YAKYEFFKNP MNFFPEQMVT WCQQSNGSQT QLLQNFLNSS SCPEIQGFLH VKELGKKSWK KLYVCLRRSG LYCSTKGTSK EPRHLQLLAD LEDSNIFSLI AGRKQYNAPT DHGLCIKPNK VRNETKELRL LCAEDEQTRT CWMTAFRLLK YGMLLYQNYR IPQQRKALLS PFSTPVRSVS ENSLVAMDFS GQTGRVIENP AEAQSAALEE GHAWRKRSTR MNILGSQSPL HPSTLSTVIH RTQHWFHGRI SREESHRIIK QQGLVDGLFL LRDSQSNPKA FVLTLCHHQK IKNFQILPCE DDGQTFFSLD DGNTKFSDLI QLVDFYQLNK GVLPCKLKHH CIRVAL

Target Information

GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus.
A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly.
GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.