Thermo Fisher Scientific CDH1 Monoclonal Antibody (OTI4F1), TrueMAB

Applications

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily.
It is a cell-cell adhesion glycoprotein containing five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
Loss of E-cadherin function contributes to cancer progression by enhancing proliferation, invasion, and metastasis.
E-cadherin also mediates bacterial adhesion and plays a key role in maintaining tissue architecture and integrity.
In humans, E-cadherin is encoded by the CDH1 gene located on chromosome 16.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.

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