Thermo Fisher Scientific LSD1 Polyclonal Antibody
LSD1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 고순도 액상 형태로 제공되며, 인간 및 마우스 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific LSD1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 108–142 amino acids from the N-terminal region of human LSD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2058175 |
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a marker for epigenetic transcriptional activation, thereby acting as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is part of several histone deacetylase complexes and silences genes through demethylation activity. It oxidizes substrates via FAD to form imine intermediates that are hydrolyzed. LSD1 demethylates both mono- and tri-methylated Lys-4 of histone H3 and may repress neuronal genes. It requires RCOR1/CoREST for nucleosomal demethylation activity and may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes. Mutations in this gene are associated with cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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