Thermo Fisher Scientific Phospho-Tau (Ser199) Recombinant Rabbit Monoclonal Antibody (23E8)
인간 Tau 단백질의 Ser199 인산화 형태를 인식하는 재조합 토끼 단일클론 항체로, IHC, Flow Cytometry, ELISA에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태, 안정적 PBS/glycerol 보존. 신경퇴행성 질환 연구에 적합.
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Thermo Fisher Scientific Phospho-Tau (Ser199) Recombinant Rabbit Monoclonal Antibody (23E8)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23E8 |
| Immunogen | A synthesized peptide derived from Human MAPT (aa 199) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092539 |
Target Information
Tau is a neuronal microtubule-associated protein predominantly located on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, functioning as a linker between both structures. Tau localization determines axonal polarity in neurons. Short isoforms contribute to cytoskeletal plasticity, while longer ones aid stabilization.
In its hyper-phosphorylated form, Tau becomes the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation disrupts microtubule binding, destabilizing microtubules and leading to neuronal degeneration. Multiple kinases, including GSK-3β, PKA, CDK5, and casein kinase II, phosphorylate Tau. Hyper-phosphorylated Tau is also present in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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