Thermo Fisher Scientific CBX4 Polyclonal Antibody
CBX4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫 등 다양한 종에 반응. 합성 펩타이드 항원을 이용해 제작되었으며, 액상 형태로 -20°C에서 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CBX4 (Accession O00257), corresponding to amino acid residues T94–P144 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899585 |
Product Specific Information
Antibody detects endogenous levels of total CBX4.
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins important for embryonic and adult stem cell self-renewal and maintenance. Two distinct human PcG complexes have been identified.
Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation.
Depletion of CBX4 reduces cellular resistance to ionizing radiation and is directly involved in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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