Thermo Fisher Scientific GPR37 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GPR37.

Target Information

Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s. About 1% of people over the age of 65 and 3% over 75 are affected. The mutation is the most common cause of Parkinson’s disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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