Thermo Fisher Scientific PRPF18 Polyclonal Antibody
Human PRPF18 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. E. coli 유래 항원으로 생산되었으며, Antigen affinity chromatography로 정제됨. PBS buffer에 보관하며 -20°C에서 안정적 저장 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human PRPF18 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2902797 |
Target Information
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. It belongs to the PRP18 family and contains seven WD repeats. PRPF18 exists as two alternatively spliced isoforms encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN, an important tumor suppressor gene on chromosome 10, when defective, leads to Cowden syndrome, a cancer predisposition condition. Other disorders associated with chromosome 10 include Cockayne syndrome, tetrahydrobiopterin deficiency, and trisomy 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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