Thermo Fisher Scientific MIOS Polyclonal Antibody
Human MIOS 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관. mTORC1 신호 경로 연구용으로 적합.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MIOS. Recombinant protein control fragment (Product #RP-106384) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664963 |
Product Specific Information
Immunogen sequence:
SISYSCSAVPH QGRGFSQYGV SGSPTKSKVT SCPGCRKPLP RCALCLINMG TPVSSCPGGT KSDEKVDLSK DKKLAQFNNW FTWCHNCRHG GHAGHMLSWF RDHAECPVSA CTCKCMQLD
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
As a component of the GATOR subcomplex GATOR2, MIOS functions within the amino acid-sensing branch of the TORC1 signaling pathway. It indirectly activates mTORC1 and the TORC1 signaling pathway through inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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