Thermo Fisher Scientific IMP3 Polyclonal Antibody
Western blot과 Immunoprecipitation에 적합한 Rabbit Polyclonal Antibody. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제됨. 4°C에서 보관하며 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 529 and 579 of human Insulin-Like Growth Factor 2 mRNA Binding Protein 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi and is more abundant in metastatic melanomas compared to thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biological behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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