Thermo Fisher Scientific Protein APC Monoclonal Antibody (KT45)
Mouse 단백질 APC를 인식하는 Rat IgG2a 단클론 항체로, Western blot 및 면역형광(ICC/IF)에 적합. GST 융합 APC 단백질(aa 2170–2394)을 면역원으로 사용. Protein G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KT45 |
| Immunogen | Adenomatous polyposis coli (APC) protein fused to GST (aa 2170–2394) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | 2–8°C (최대 1개월), 장기 보관 시 -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_923265 |
Target Information
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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