Thermo Fisher Scientific IL17RB Polyclonal Antibody
IL17RB 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 ELISA에 적합. Human, Mouse, Rat에 반응하며, 액상 형태로 제공. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장. 연구용으로 세포막 단백질 검출에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 18–292 of human IL17RB (NP_0611952) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2804338 |
Product Specific Information
Immunogen sequence:
REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP
Positive Samples: HepG2, 293T, SW620, A-549, B-cell, Mouse liver, Rat liver
Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
A number of cytokines belonging to the interleukin (IL)-17 family have been identified, including IL-17B, IL-17C, and IL-17E. IL-17 is a potent proinflammatory cytokine involved in diseases such as rheumatoid arthritis, multiple sclerosis, and tumor progression. IL-17B, C, and E can induce proinflammatory responses but do not bind to the IL-17 receptor, suggesting the existence of additional IL-17R-related receptors. The receptor for IL-17B and IL-17E has been identified as EV127 (mouse) and IL-17Rh1 (human). IL-17E activates the NF-κB pathway and promotes IL-8 production. IL-17Rh1 mRNA is highly expressed in kidney and liver, and moderately in small intestine, colon, and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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