Thermo Fisher Scientific RIC8A Polyclonal Antibody
Rabbit 유래 다클론 항체로, Western blot 및 Immunoprecipitation에 적합. Human RIC8A 단백질을 인식하며, 비결합(Unconjugated) 상태로 제공. 세포 신호전달 연구 및 G단백질 활성화 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 5–10 µL/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human RIC8A fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866906 |
Target Information
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.
Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS, by exchanging bound GDP for free GTP.
Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release of G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex.
Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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