Thermo Fisher Scientific Dynamin 3 Polyclonal Antibody
Rabbit polyclonal antibody targeting Dynamin 3 for WB, ICC/IF, and ELISA applications. Reacts with mouse and rat samples. High purity (Affinity Chromatography) and stable liquid form with 50% glycerol. Suitable for research use in cytoskeletal studies.
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- PA590253
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 410–555 of human Dynamin 3 (NP_0012651811) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.34 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805984 |
Product Specific Information
- Immunogen sequence: EAIVKKQIVK LKGPSLKSVD LVIQELINTV KKCTKKLANF PRLCEETERI VANHIREREG KTKDQVLLLI DIQVSYINTN HEDFIGFANA QQRSSQVHKK TTVGNQVIRK GWLTISNIGI MKGGSKGYWF VLTAESLSWY KDDENI
- Positive Samples: Mouse brain, rat brain
- Cellular Location: Cytoplasm, cytoskeleton
Target Information
The dynamins are a family of 100 kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located before a proline-rich domain (PRD). The PRD mediates interactions between dynamin and numerous other cellular proteins.
Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is restricted to expression in brain, testis, heart, and lung. Dynamins participate in clathrin-mediated and fluid-phase endocytosis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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