Thermo Fisher Scientific BAP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, and Bovine.

Target Information

BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin.
BAP1 contains an acidic region, a highly charged C-terminal region, and two putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns, with BAP1 enhancing BRCA1-mediated inhibition of breast cancer cell growth.
Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with a 4.8-kb transcript expressed exclusively in testis. BAP1 and BRCA1 are coexpressed during murine breast development and remodeling.
The BAP1 gene is mapped to 3p21.3, a region frequently deleted in lung carcinomas and associated with loss of heterozygosity in breast cancer. Intragenic rearrangements and deletions of BAP1 appear in lung carcinoma cell lines, suggesting BAP1 functions as a tumor suppressor gene in the BRCA1 growth control pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.